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doi: 10.1016/j.canlet.2006.10.029

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While several reports demonstrate that Nrf2 signaling can be induced by oxidative stress in neurons [120], it has been recently suggested that neuronal Nrf2 is epigenetically silenced [33], and that induction of the Nrf2 pathway does not seem to restore their antioxidant protection (Figure 1.5) [152]